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Skorjanec et al., 2009

Chronic inflammation is another important driver of alopecia, leading to premature follicular regression and impaired regeneration [3, 4, 24]

John s Wort induces CYP3A4 and can reduce plasma concentrations of PPIs like omeprazole, while curcumin and berberine can inhibit CYP3A4 and P-glycoprotein, raising toxicity risks with drugs such as warfarin, statins, or immunosuppressants